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目的 研究1 3 N NH3 ·H2 O的临床前药理、PET显像方法及其在心肌显像中的应用。方法 进行犬全身和动态心肌PET显像 ,测定1 3 N NH3 ·H2 O在犬体内的分布 ,并对健康志愿者进行心肌PET显像。结果 心肌PET显像发现 ,心脏和肺是首过器官 ,心肌摄取率最高。心肌摄取快而清除相对较慢 ,血、肝和肺的本底清除快 ,心脏影像清晰。注射1 3 N NH3 ·H2 O后 30s,左右心室放射性达到峰值 ,1min后开始下降 ,在 4～ 2 0min保持相对平稳的水平 ;左心室间壁和侧壁心肌在注射后 10s开始摄取 ,间壁摄取高于侧壁 ,2min后侧壁摄取略高于间壁 ;肝和肺在第 30s摄取达峰值 ,此后急剧下降 ,5min后摄取逐渐下降并维持在较低的水平 ,心 肝和心 肺比值均高于 2 0。动物全身显像发现 ,1 3 N NH3 ·H2 O主要分布在血液供应丰富的组织 ,主要经肾脏清除。动态心肌显像和注射1 3 N NH3 ·H2 O 4～ 5min后进行的静态显像可获得一致的心肌血流灌注图像。结论 1 3 N NH3 ·H2 O有较高的心 肝和心 肺比值 ,灌注图像清晰 ,是理想的心肌血流灌注显像剂。
Objective To study the preclinical pharmacology and PET imaging of 1 3 N NH3 · H2 O and its application in myocardial imaging. Methods Whole body and dynamic myocardial PET imaging were performed in dogs. The distribution of 13N NH3 · H2 O in dogs was determined and myocardial PET imaging was performed in healthy volunteers. Results myocardial PET imaging found that the heart and lungs are the first organ, the highest myocardial uptake rate. Fast myocardial uptake and removal of relatively slow, clear background of blood, liver and lungs clear, clear heart images. At 30 s after injection of 1 3 N NH 3 · H 2 O, the radioactivity of the left ventricle and the right ventricle peaked and decreased after 1 min, and remained relatively stable at 4 ~ 20 min. The left ventricular wall and side wall myocardium uptake 10 s after injection, In the side wall, the wall uptake was slightly higher than the partition wall after 2 minutes. The uptake of liver and lung peaked at the 30th hour, and then dropped sharply. After 5 minutes, the uptake gradually decreased and maintained at a low level. . Whole-body imaging of animals found that 13 N NH 3 .H 2 O mainly distributes in blood-rich tissues and is mainly cleared by the kidneys. Dynamic myocardial imaging and injection of 1 3 N NH 3 · H 2 O 4 ~ 5min after static imaging can be obtained consistent myocardial perfusion images. Conclusion 1 3 N NH 3 .H 2 O has higher heart, liver and heart-lung ratios, and clear perfusion images, making it an ideal myocardial perfusion imaging agent.