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目的观察酪酸梭菌活菌散(商品名:宝乐安)预防新生儿高胆红素血症的临床疗效。方法将产科分娩的正常足月新生儿212例,随机分为2组,预防组106例,对照组106例,2组均在生后半小时内开始喂奶。预防组喂服酪酸梭菌活菌散500 mg/次,3次/d,用至黄疸消退,观察黄疸变化情况及不良反应。结果出生后48 h内胎便转黄率预防组为56.6%,对照组为26.4%;生后7 d内皮肤巩膜黄染达高峰预防组为58.5%,对照组为43.3%;高胆红素血症发生率预防组为7.5%,对照组为22.6%;出生后7 d内血清胆红素达高峰率预防组为62.3%,对照组为47.1%。以上各指标2组间差异均具有统计学意义(P<0.01或0.05)。结论酪酸梭菌活菌散预防新生儿高胆红素血症安全有效,值得临床推广应用。
Objective To observe the clinical efficacy of Clostridium butyricum viable bacteria (brand name: Baile Ann) in preventing neonatal hyperbilirubinemia. Methods A total of 212 normal full-term newborns with obstetric delivery were randomly divided into 2 groups: prevention group (106 cases) and control group (106 cases). Both groups started feeding within half an hour after birth. Preventive group fed Clostridium butyricum viable 500 mg / time, 3 times / d, with jaundice subsided, observed jaundice changes and adverse reactions. Results Within 48 hours after birth, the rate of penicillin in prevention group was 56.6% in the control group and 26.4% in the control group. In the 7 days after birth, the sclera of the sclera group reached 58.5% in the peak prevention group and 43.3% in the control group. Hyperbilirubinemia The incidence of disease was 7.5% in the prevention group and 22.6% in the control group. The prevention rate of bilirubin in the prevention group was 62.3% within 7 days after birth and 47.1% in the control group. The above indicators between the two groups were statistically significant differences (P <0.01 or 0.05). Conclusion Clostridium butyricum is safe and effective in preventing neonatal hyperbilirubinemia and is worthy of clinical application.