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目的:分析海南省恙虫病患者流行现况及临床特点，为当地恙虫病诊疗及预防控制提供依据。方法:收集2018年1月至2019年12月海南医学院第二附属医院收治的93例恙虫病患者临床资料，回顾性分析患者基本流行病学特征、临床特征、辅助检查、治疗情况。结果:93例恙虫病患者中，男性和女性分别为48和45例，平均年龄为50.73岁；发病时间高峰为6 - 10月，共46例（49.46%）；农民为主要发病人群，共70例（75.27%）；84例患者（90.32%）在发病前有明确的田间劳作、草地或丛林接触史。临床特征为发热（93/93，100.00%）、焦痂或溃疡（42/93，45.16%）、头痛（65/93，69.89%）、畏寒寒战（60/93，64.52%）、皮疹（35/93，37.63%）、淋巴结肿大（51/93，54.84%）、全身乏力（40/93，43.01%）等。实验室指标主要表现为嗜酸粒细胞减少（74/93，79.57%）、血小板计数降低（32/93，34.41%），丙氨酸氨基转移酶（76/93，81.72%）、C反应蛋白（91/93，97.85%）、降钙素原（19/93，20.43%）、红细胞沉降率（67/93，72.04%）升高。患者胸部影像学检查结果异常84例（90.32%）；所有患者经多西环素治疗后均治愈。结论:海南恙虫病流行高峰为夏秋季节，临床表现多样，多西环素是有效的治疗药物，建议相关部门加强当地临床医师对恙虫病临床诊疗培训，降低误诊率。“,”Objective:To analyze the epidemiological and clinical characteristics of patients with tsutsugamushi disease in Hainan Province, so as to provide basis for diagnosis, treatment, prevention and control of the disease.Methods:Clinical data of 93 patients with tsutsugamushi disease in the Second Affiliated Hospital of Hainan Medical University from January 2018 to December 2019 were collected. Epidemiological data, clinical manifestations, examination results, treatment and outcome of the patients were retrospectively analyzed.Results:Of totally 93 patients with tsutsugamushi disease, 48 were male and 45 were female, with an average age of 50.73 years old. The peak time of onset was from June to October, with 46 cases (49.46%). Seventy cases (75.27%) were farmers, and 84 cases (90.32%) had a clear history of field work or grassland contact before onset. The clinical manifestations were fever (93/93, 100.00%), eschar or ulcer (42/93, 45.16%), headache (65/93, 69.89%), chills (60/93, 64.52%), rash (35/93, 37.63%), lymphadenopathy (51/93, 54.84%) and fatigue (40/93, 43.01%). Laboratory examination results: eosinophil reduced (74/93, 79.57%), platelet reduced (32/93, 34.41%); alanine aminotransferase, C reactive protein (CRP), procalcitonin (PCT) and erythrocyte sedimentation rate (ESR) were increased in 81.72% (76/93), 97.85% (91/93), 20.43% (19/93) and 72.04% (67/93) of the patients, respectively. Eighty-four cases (90.32%) had abnormal results of chest imaging. All patients were cured by doxycycline.Conclusions:Tsutsugamushi disease is prevalent in summer and autumn in Hainan. It has various clinical manifestations. Doxycycline is an effective treatment drug. It is suggested that the relevant departments should strengthen the training of clinical diagnosis and treatment of tsutsugamushi disease by local clinicians to reduce the misdiagnosis rate.