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目前临床多以血清免疫学乙型肝炎病毒标志作为诊断乙型肝炎的主要依据之一。但随着PCR方法对血清中HBV DNA检测及采用免疫组化法对肝组织HBsAg、HBcAg检测的开展,发现血清HBVM阴性并不能排除HBV感染的存在。为此,对近年来就诊病例进行了研究,目的在于了解血清中HBVM阴性而有病毒复制者的临床意义。
At present, the clinical diagnosis of hepatitis B is one of the main reasons for the clinical diagnosis of hepatitis B with serum immunological hepatitis B virus. However, with the detection of HBV DNA in serum by PCR method and the detection of HBsAg and HBcAg in liver tissue by immunohistochemistry, it is found that the serum HBVM negative can not rule out the existence of HBV infection. To this end, the study of cases in recent years were studied, the purpose is to understand the clinical significance of serum HBVM negative and viral replication.