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本文采用放免测定对63例妊娠合并肝内胆汁郁积症(ICP)的患者进行血清甘胆酸(CG)含量测定,结果表明CG值在诊断ICP中比转氨酶灵敏,其异常值,前者为100%,后者为83%。因此妊娠期瘙痒、CG值增高或伴有转氨酶及/或胆红素的增高是ICP严重程度不同的表现。且CG值的增高倍数与胎)L宫内窘迫的发生率有关(P<0.05)。在CG值异常组中必须动态观察临床和实验室各项指标的变化,用胎儿监护仪,加强产前、产时的胎儿监护,及时破膜,了解羊水性状,以选择适当的分娩方式。
In this paper, 63 cases of pregnancy with intrahepatic cholestasis (ICP) were measured by radioimmunoassay in patients with serum glycocholic acid (CG) content of the results showed that the CG value in the diagnosis of ICP than aminotransferase sensitivity, the abnormal value, the former is 100% , The latter is 83%. Therefore, pruritus during pregnancy, CG value increased or accompanied by elevated transaminases and / or bilirubin are ICP manifestations of different severity. The increase of CG value was related to the incidence of intrauterine distress (P <0.05). In abnormal CG group, the changes of clinical and laboratory indexes must be dynamically observed. Fetal monitor should be used to strengthen prenatal and intrauterine fetal monitoring, timely rupture of membranes, understanding of amniotic fluid traits, and choosing the appropriate mode of delivery.