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在甾体的甾核或支链上引入不同的官能团后可得到不同生理活性的化合物,它们有可能会成为人类治疗不同疾病的药物,因此甾体药物除了作为传统激素类药物使用外,在抗肿瘤药物、抗炎药物中的应用也成为甾体的重要研究内容之一。含有酰胺官能团的甾体化合物具有很好的生物活性。本文按照酰胺基团在甾体酰胺化合物中的位置进行分类,同时结合本课题组在甾体酰胺化合物的合成和生理活性研究方面所取得的一些成果,概述了近几年来新合成及发现的甾体酰胺类化合物及其衍生物的生理活性及研究进展,包括作为抗肿瘤药物的甾体酰胺化合物的设计、筛选、对5α-还原酶的抑制作用、抑制肿瘤细胞生长增殖活性及抗菌作用,并对此方面的发展趋势、应用前景作了展望。
The introduction of different functional groups on the steroidal nucleus or the branches of the steroid leads to different physiologically active compounds which may become human drugs for treating different diseases. Therefore, steroid drugs, besides being used as traditional hormone drugs, Tumor drugs, anti-inflammatory drugs in the application of steroids has also become an important part of the study. Steroid compounds containing amide functionalities have good bioactivity. In this paper, according to the position of amide groups in steroid amide compounds, we also summarize the results obtained in recent years on the synthesis and the discovery of steroids in our group in the synthesis and physiological activity of steroid amide compounds Physiological activity of body amide compounds and their derivatives and their research progress include the design and screening of steroid amide compounds as anti-tumor drugs, inhibition of 5α-reductase, inhibition of tumor cell growth and proliferation and antibacterial activity, and In this respect, the development trend and application prospect are prospected.