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目的采用Meta分析方法综合分析和评价国内外发表的有关老年男性骨密度与牙周炎关系的相关文献,为有效防治老年男性骨质疏松症、牙周炎提供科学依据。方法于2011年1—4月在广州医学院第二附属医院联合检索国内外的医学文献数据库,获取国内外有关老年男性骨密度与牙周炎危险因素关系的病例对照研究资料。按标准筛选文献,然后进行文献评价和Meta分析。结果共检出相关文献137篇,其中8篇符合入选标准。8篇论著累计样本量4038人,其中牙周炎1794人。总效应测定结果显示牙周炎组与非牙周炎组老年男性骨密度差异有统计学意义(Z=3.14,P=0.002),老年男性骨密度降低者患牙周炎的风险比骨密度水平正常者高;WMD及95%CI为-0.01(上限-0.01,下限-0.02)。结论老年男性骨密度与牙周炎的发病具有相关性。
Objective To comprehensively analyze and evaluate the published literature about the relationship between bone mineral density and periodontitis in elderly men by Meta-analysis, and provide a scientific basis for effective prevention and treatment of osteoporosis and periodontitis in the elderly. Methods From January to April of 2011, the medical literature databases of both domestic and overseas were searched jointly by the Second Affiliated Hospital of Guangzhou Medical College to obtain the case-control study data on the relationship between bone mineral density and periodontal risk factors in elderly men at home and abroad. The literature is screened to the standard, followed by literature review and meta-analysis. Results A total of 137 articles were found, of which 8 met the inclusion criteria. 8 papers a total of 4038 samples, of which 1794 people with periodontitis. The total effect measurement showed that there was a significant difference in bone mineral density between the periodontitis group and the non-periodontitis group (Z = 3.14, P = 0.002). The risk of periodontitis in the elderly men with lower BMD was higher than that of BMD Normal high; WMD and 95% CI -0.01 (upper limit -0.01, lower limit -0.02). Conclusion There is a correlation between bone density and the incidence of periodontitis in the elderly.