苯乙甙类(Phenylethanoids)化合物是 一种从药用植物中分离出来的有许多活性的成分,已知有抗炎、镇痛、免疫等作用。研究发现,从肉苁蓉(Cistanche deserticola)中分离出的9种苯乙甙具有抗脂质过氧化、清除自由基的作用。此次着重研究其中4种活性最强的苯乙甙的保肝作用。这4种苯乙甙为acteoside(1)、2′-acetylacteoside(2)、isoacteoside(3)、tubuloside B(4)。采用CCl_4和D-半乳糖胺(D-Gal N)诱导的肝毒性体外试验和CCl_4中毒的体内试验。 Phenylethanoids are a variety of active ingredients isolated from medicinal plants and are known to have anti-inflammatory, analgesic, and immunological effects. The study found that nine phenelzines isolated from Cistanche deserticola have anti-lipid peroxidation and free radical scavenging effects. The focus of this study was on the hepatoprotective effects of 4 of the most active phenelzines. The four kinds of phenelzines are acteoside (1), 2’-acetylacteoside (2), isoacteoside (3), and tubuloside B (4). In vitro tests for hepatotoxicity induced by CCl_4 and D-galactosamine (D-Gal N) and in vivo tests for CCl_4 intoxication.