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目的通过分组检测比较研究早发型重度子痫前期(EOSP)患者血清中高密度脂蛋白(HDL)水平的变化,探讨其在发病中的临床意义。方法以该院产科2011年6月~2014年6月住院治疗的60例EOSP患者为研究对象,设为研究组,并将同期60例正常健康孕妇作为对照组。对两组患者血清中HDL、抗心磷脂抗体(ACA)Ig G、Ig M滴度及载脂蛋白A1(Apo A1)含量进行检测。结果研究组患者血清中HDL含量和ACA阳性率均高于对照组,而Apo A1含量较对照组降低,两组差异有统计学意义(P<0.05);HDL含量与ACA滴度两组之间无明显相关性。结论自身免疫反应是EOSP的重要发病因素,HDL与EOSP发病有着密切关系,且功能异常的HDL在EOSP发病的恶性循环之中可能发挥着重要作用。
Objective To compare the changes of serum high density lipoprotein (HDL) in patients with early-onset severe preeclampsia (EOSP) by grouping test, and to explore its clinical significance. Methods Sixty patients with EOSP hospitalized from June 2011 to June 2014 in our hospital were enrolled as study group and 60 healthy pregnant women in the same period as control group. Serum levels of HDL, anti-cardiolipin antibodies (ACA) Ig G, Ig M titers and apolipoprotein A1 (Apo A1) levels were measured in two groups of patients. Results The levels of serum HDL and ACA in the study group were higher than those in the control group, while the levels of Apo A1 in the serum of the study group were lower than those in the control group (P <0.05). There was no significant difference between the HDL levels and the ACA titer No significant correlation. Conclusion The autoimmune reaction is an important risk factor of EOSP. HDL is closely related to the pathogenesis of EOSP. HDL may play an important role in the pathogenesis of EOSP.