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目的 观察中晚期妊娠合并严重急性呼吸综合征 (severeacuterespiratorysyndrome,SARS)对妊娠结局及胎婴儿的影响。 方法 分析 6例妊娠合并SARS的临床特征、妊娠结局 ,检测母儿SARS病毒抗体、RNA ,随访婴儿情况。 结果 6例 (双胎妊娠 2例 )SARS患者娩出新生儿 7例 ,其中早产 2例 ,胎儿窘迫 3例 ;1例双胎妊娠之一胎儿死亡 ,另一胎儿生长受限 ;新生儿均无窒息、SARS迹象。产妇冠状病毒抗体IgG均阳性 ,婴儿 4例阳性、3例阴性 ;母儿IgM抗体、病毒RNA均阴性。早产儿 (3例 )体格智能发育稍落后 ,足月儿 (4例 )正常。 结论 中晚期妊娠合并SARS对围产结局有一定的不良影响 ,但未发现SARS病毒的垂直传播。
Objective To observe the effect of severe pregnancy syndrome (SARS) on pregnancy outcome and fetus in middle and late pregnancy. Methods The clinical features of 6 pregnant women with SARS were analyzed. The outcome of pregnancy was analyzed. The antibody and RNA of the maternal and neonatal SARS virus were detected and the infants were followed up. Results In the 6 cases of twin pregnancy, 7 newborns were delivered with SARS, of which 2 were premature delivery and 3 were fetal distress. One fetus died in one twin pregnancy and the other fetus had limited growth. Neonatal asphyxia SARS signs. Maternal coronavirus antibody IgG were positive, 4 were positive in infants, 3 negative; mother and child IgM antibodies, viral RNA were negative. Premature children (3 cases) physical intelligence slightly developed, full-term children (4 cases) normal. Conclusions The incidence of perinatal outcome in moderate and advanced pregnancy combined with SARS has some adverse effects, but no vertical transmission of SARS virus is found.