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目的 探讨半乳糖凝集素3表达对鉴别良恶性甲状腺肿瘤的临床价值。方法 采用免疫化学染色法(SP法)观察72例手术切除的甲状腺肿瘤标本半乳糖凝集素3的表达。结果 半乳糖凝集素3在恶性肿瘤的细针抽吸(FNA)细胞涂片与组织切片中均高水平表达,在良性肿瘤中不表达或低表达。良性与恶性甲状腺肿瘤在FNA细胞涂片或组织切片中半乳糖凝集素3的表达差异有统计学意义(χ2 =43. 73,χ2 =48. 16,均P<0. 01)。相同性质的甲状腺肿瘤FNA细胞涂片与组织切片的半乳糖凝集素3表达一致,两者之间差异无统计学意义(χ2 =0. 04,χ2 =0. 19,均P>0. 05)。结论 半乳糖凝集素3在良恶性甲状腺肿瘤中表达不同,恶性肿瘤中表达显著增高,是鉴别良恶性甲状腺肿瘤可靠的分子标记物,可用于FNA涂片标本及组织标本检测。
Objective To investigate the clinical value of galectin-3 expression in differential diagnosis of benign and malignant thyroid neoplasms. Methods Immunohistochemistry (SP method) was used to observe the expression of galectin-3 in 72 surgically resected thyroid tumors. Results Galectin-3 was highly expressed in fine needle aspiration (FNA) cell smears and histological sections of malignant tumors, but not in benign tumors. The difference was statistically significant between benign and malignant thyroid tumors in FNA cell smear or tissue section of galectin-3 (χ2 = 43.73, χ2 = 48.16, both P <0.01). The same type of thyroid tumor FNA cells smear and tissue sections of galectin 3 expression, the difference was not statistically significant (χ2 = 0.4, χ2 = 0.19, both P> 0.05) . Conclusion The expression of galectin-3 in benign and malignant thyroid neoplasms is different. The expression of galectin-3 is significantly increased in malignant tumors. It is a reliable molecular marker for differentiating benign and malignant thyroid neoplasms. It can be used for the detection of FNA smears and tissue samples.