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目的 探讨p15 ,血管内皮生长因子 (VEGF)与胃癌临床病理因素的关系。方法 应用免疫组织化学 (S P)方法测定胃癌及胃良性病变中p15 ,VEGF表达。结果 胃癌中p15阳性率 (4 3 75 % )低于胃良性病变 (6 9 2 3 % ) (P <0 .0 5 )。p15表达与临床病理因素无关。VEGF阳性率胃癌组为 75 0 0 % ,胃良性病变组为 7 6 9% (P <0 .0 0 1) ;胃癌中浸润深度不超过粘膜下层组为 42 86 % ,浸润肌层组为 5 1 72 % ,浸润浆膜层组为 95 45 % (P<0 .0 0 1) ;有淋巴结转移组为 82 76 % ,无淋巴结转移组为 5 4 5 6 % (P <0 .0 5 ) ;伴远处转移组为 10 0 % ,不伴远处转移组为 71 10 % (P <0 .0 5 ) ;pTNM分期Ⅰ ,Ⅱ组为 5 3 13 % ,Ⅲ ,Ⅳ组为 89 5 6 % (P <0 .0 0 1) ;溃疡组为 81 97% ,浸润型组为 40 0 0 % (P <0 .0 5 )。p15(- )与VEGF(+ )具有显著相关性 (P <0 .0 0 1)。p15 (- ) VEGF(+ )联合表达率胃癌组为42 5 0 % ,胃良性病变组为 7 6 9% (P <0 .0 1)。结论 胃癌中存在p15下调与VEGF上调 ,且二者具有相关性。p15表达与临床病理因素无关 ,VEGF表达与胃癌临床病理因素相关
Objective To investigate the relationship between p15, vascular endothelial growth factor (VEGF) and clinicopathological factors in gastric cancer. Methods The expressions of p15 and VEGF in gastric cancer and gastric benign lesions were determined by immunohistochemistry (S P). Results The positive rate of p15 in gastric cancer (43 75%) was lower than that in benign gastric lesions (6923%) (P 0.05). The expression of p15 was not related to clinicopathological factors. The positive rate of VEGF was 75 0% in gastric cancer group and 76.9% in gastric benign lesion group (P <0.01). The depth of invasion in gastric cancer group was 42 86% in submucosa group and 5 (P <0.01). The percentage of lymph node metastasis group was 82.76% and the rate of non-lymph node metastasis group was 54.56% (P <0.05) ; With distant metastasis group was 10%, without distal metastasis was 71 10% (P <0.05); pTNM stage Ⅰ, Ⅱ group was 533%, Ⅲ, Ⅳ group was 89 5 6 % (P0.001). The ulcer group was 81.97% and the infiltrative group was 40.0% (P <0.05). There was a significant correlation between p15 (-) and VEGF (+) (P <0.001). The positive rate of p15 (-) VEGF (+) expression was 42 50% in gastric cancer group and 76.9% in gastric benign disease group (P <0.01). Conclusions There is a correlation between p15 downregulation and VEGF upregulation in gastric cancer. The expression of p15 was not related to clinicopathological factors, and the expression of VEGF was related to the clinicopathologic factors of gastric cancer