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目的 探讨可溶性白细胞介素 2受体 (sIL 2R)和可溶性白细胞介素 6受体 (sIL 6R)在多发性硬化(MS)发病过程中的作用。方法 采用双体夹心ELISA法对 2 9例MS急性期患者及 2 0例炎性神经病患者、39例非炎性神经病患者、2 0例健康对照者脑脊液和血清中sIL 2R和sIL 6R的含量进行检测。结果 MS患者血清和脑脊液中sIL 2R、sIL 6R含量明显高于非炎性神经病组 (P <0 .0 5 )及健康对照组 (P <0 .0 1) ;MS组sIL 2R和血清sIL 6R含量与炎性神经病组比较 ,无显著性差异 ,但脑脊液中sIL 6R水平明显低于炎性神经病组 (P <0 .0 1)。结论 sIL 2R和sIL 6R在MS急性期患者体内明显升高 ,进一步证实了MS有关免疫学的发病机制 ,并为临床诊断MS提供了具有参考价值的实验室指标
Objective To investigate the role of soluble interleukin 2 receptor (sIL 2R) and soluble interleukin 6 receptor (sIL 6R) in the pathogenesis of multiple sclerosis (MS). Methods Serum levels of sIL 2R and sIL 6R in 29 acute MS patients and 20 patients with inflammatory neuropathy, 39 patients with non-inflammatory neuropathy and 20 healthy controls were measured by sandwich ELISA. Detection. Results The levels of sIL 2R and sIL 6R in serum and cerebrospinal fluid of MS patients were significantly higher than those in non-inflammatory neuropathies (P <0.05) and healthy controls (P <0.01). MSIL sIL 2R and serum sIL 6R The content of sIL 6R in cerebrospinal fluid was significantly lower than that in inflammatory neuropathy group (P <0.01). Conclusion The sIL 2R and sIL 6R in patients with acute MS were significantly increased, further confirming the pathogenesis of MS-related immunology, and provide a valuable laboratory index for the clinical diagnosis of MS