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口腔粘膜炎是癌症病人接受大剂量化疗或放疗后经常发生的副反应。若内源性的微生物或病原体扩散后,其损伤程度可能加剧,随后引发全身性感染。Iseganan盐酸盐(IB-367)是Intra Biotics公司开发成功的一种新的抗微生物多肽,是以人体内发现的天然蛋白溶菌素(protegrin,PG)为基础合成的。Iseganan盐酸盐能与细菌的胞外成分如脂
Oral mucositis is a frequently occurring side effect of cancer patients receiving high-dose chemotherapy or radiotherapy. If the endogenous microorganisms or pathogens spread, the degree of damage may be increased, followed by systemic infection. Iseganan hydrochloride (IB-367) is a new antimicrobial peptide developed by Intra Biotics that is based on the discovery of the natural protegrin (PG) found in the body. Iseganan hydrochloride can interact with extracellular components of bacteria such as lipids