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刺激麻醉大鼠一侧腓总神经,在同侧L_(3-4)硬膜外的背柱部位记录到脊髓诱发电位(SEP),由快三相峰电位A波,慢负波N_1,N_2及正波P组成。这些电位在2—4小时的空白对照观察中,保持稳定。在压强分级递增压迫L_(4-5)及其尾侧邻近节段过程中,A波潜伏期未见变化;A波和N波峰潜伏期随压强递增而延长;A波、N波和P波幅度随压强递增呈线性下降;在压强值增到225mmHg(X)时,N波和P波消失,A波残留并变成最后电位。压强达300mmHg并持续5分钟后去除压迫时,SEP各波幅度在15分钟内迅速恢复到一定程度,然后恢复变得缓慢;慢波幅度较快波幅度恢复明显;A波峰潜伏期与幅度同步的恢复,N波峰潜伏期落后于幅度的恢复,实验结果表明:脊髓对机械压迫敏感,脊髓功能减低与压强增高呈线性关系。
The common peroneal nerve on one side of the anesthetized rat was stimulated and the spinal cord evoked potential (SEP) was recorded on the ipsilateral L_ (3-4) epidural column. The results showed that the spinal cord evoked potentials (AEPs), slow negative N_1, N_2 And positive wave P composition. These potentials remained stable during the 2-4 hours of blank control. There was no change in the latency of A wave during the step-up compression of L_ (4-5) and its caudal adjacent segments. The latency of A wave and N wave increased with increasing pressure. The amplitude of A wave, N wave and P wave As the pressure increases to 225mmHg (X), N wave and P wave disappear, and A wave remains and becomes the final potential. When the pressure reaches 300mmHg for 5 minutes and the pressure is removed, the amplitudes of the SEPs rapidly recover to a certain extent within 15 minutes, then the recovery becomes slow; the amplitude of the rapid wave of the slow wave resumes obviously; the recovery of the peak latency and the amplitude of A synchronously , N wave latency lags behind the recovery of amplitude, the experimental results show that: the spinal cord is sensitive to mechanical compression, spinal cord function decreased and pressure increases linearly.