苯二氮(艹卓)(Ⅰ)的药理作用是通过中枢神经系统特殊的结合部位传递的。“苯二氮(艹卓)受体”对于药理和临床上具有活性的苯二氮(艹卓)类药物有很高的专一性。和Ⅰ不同而能与那些受体结合的一组化合物是β-咔啉类化合物。其中β-咔啉-3-羧酸酯类比母体酸的亲合力大三个数量级(低纳摩尔范围),使得β-咔啉衍生物成为研究苯二氮(艹卓)受体机能的重要工具。再者其结构能成为设计苯二氮(艹卓)类新药的重要基础。 The pharmacological effects of benzodiazepines (I) are transmitted through specific binding sites in the central nervous system. Benzodiazepines are highly specific for pharmacologically and clinically active benzodiazepines. One group of compounds that bind to those receptors differently from I is the beta-carboline compound. Among them, β-carboline-3-carboxylate has three orders of magnitude affinity (lower nanomolar range) than the parent acid, making β-carboline derivatives an important tool for studying the benzodiazepine receptor function . Furthermore, its structure can become an important basis for the design of benzodiazepines.