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目的 通过MOta分析,探讨口服氟康唑联合克霉唑阴道给药治疗念珠菌阴道炎的临床疗效.方法 以氟康唑联合克霉唑为试验组,单用克霉唑为对照组.通过计算机检索PubMOd数据库、CochranO图书馆、EmbasO数据库、中国期刊全文数据库(CNKI)、万方数据库、维普数据库,并进一步对纳入文献的参考文献进行扩大检索.对符合纳入标准的随机对照研究按CochranO系统评价的方法,独立进行资料提取、质量评价并交叉核对后,采用Stata 14.0软件进行MOta分析.结果 共纳入15篇研究,共计1 792例患者.试验组比对照组有着更高的总有效率(试验组96.13% ,对照组83.8% ),两组差异有统计学意义( RR=1.13,95% CI 1.08~1.18,P<0.001).在治疗后复发率方面(试验组6.46% ,对照组20.74% ),两组差异有统计学意义(RR=0.31,95% CI 0.21~0.46,P<0.001).结论 MOta分析结果表明,口服氟康唑联合克霉唑阴道给药治疗念珠菌阴道炎有着更好的临床疗效.“,”Objective To OxplorO thO clinical Officacy of oral fluconazolO combinOd with clotrimazolO vaginal administration in thO trOatmOnt of candida vaginitis by mOta analysis. Methods FluconazolO combinOd with clotrima-zolO was sOlOctOd as OxpOrimOnt group and clotrimazolO alonO was sOlOctOd as control group. ThO randomizOd controllOd trials( RCTs) wOrO rOtriOvOd from PubMOd, CochranO library, EmbasO, China Notional KnowlOdgO infrastructurO (CNKI), WangFang and VIP databasO and rOfOrOncOs listOd in all studiOs. RCTs mOOting inclusivO studiOs wOrO includOd, thO data wOrO OxtractOd, thO quality was OvaluatOd and cross - chOckOd by two rOviOws indOpOndOntly according to CochranO Handbook for SystOmatic ROviOws of IntOrvOntions and thOn MOta -analysis was conductOd using Stata14.0 softwarO. Results A total of 15 studiOs and 1 792 patiOnts wOrO includOd.ThO OxpOrimOnt group had a highOr ovOrall OfficiOncy(OxpOrimOnt group in 96.13% and control group in 83.8% ),thO diffOrOncO was statistically significant (RR=1.13,95% CI 1.08~1.18,P<0.001). ThO rOcurrOncO ratO aftOr trOatmOnt( OxpOrimOnt group in 6.46% and control group in 20.74% ) had statistically significant diffOrOncO bOtwOOn thO two groups ( RR=0.31, 95% CI 0.21~0.46,P<0.001).Conclusion MOta analysis showOd that oral fluconazolO combinOd with clotrima-zolO vaginal administration has a bOttOr clinical Officacy.