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[目的]探讨胃肠激素对肝衰竭大鼠胃肠动力障碍的影响。[方法]40只Wistar大鼠随机分为肝衰竭模型组和对照组,采用葡聚糖蓝-2000为胃肠内标记物,观察大鼠胃排空及肠道传输的变化,同时测定大鼠血浆及胃肠组织中胃动素(MTL)、P物质(SP)及生长抑素(SS)的含量。[结果]与对照组比较,肝衰竭模型组大鼠胃排空及小肠动力明显减弱(P<0.01),血浆及胃窦、空肠组织中生长抑素的含量明显增加(P<0.01或P<0.05),P物质的含量则显著减少(P<0.01),但胃动素的含量无明显变化。[结论]肝衰竭大鼠胃肠功能下降与P物质及生长抑素的变化有关,胃动素在其中可能不起作用。
[Objective] To investigate the effect of gastrointestinal hormones on gastrointestinal motility disorders in rats with liver failure. [Methods] Forty Wistar rats were randomly divided into liver failure model group and control group. Dextran Blue-2000 was used as a marker of gastrointestinal tract to observe the changes of gastric emptying and intestinal transit in rats. Simultaneously, the rats Contents of motilin (MTL), substance P (SP) and somatostatin (SS) in plasma and gastrointestinal tissues. [Results] Compared with the control group, the gastric emptying and small intestine motility in the model rats of liver failure were significantly decreased (P <0.01), and the contents of somatostatin in plasma, gastric antrum and jejunum were significantly increased (P <0.01 or P < 0.05), P substance content was significantly reduced (P <0.01), but there was no significant change in the content of motilin. [Conclusion] The decline of gastrointestinal function in rats with liver failure is related to the changes of substance P and somatostatin, and motilin may not play a role in them.