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目的 探讨人端粒酶逆转录酶 (HTERT)在鼻咽癌中的表达水平及其临床意义。方法 用免疫组化法检测HTERT在鼻咽癌、鼻咽粘膜上皮非典型增生组织及鼻咽慢性炎性黏膜中的表达 ,结合临床TNM分期、淋巴结及远处转移情况以及预后生存期等进行分析。结果 ⑴鼻咽癌组织HTERT的阳性率为 83 4% (70 /84) ,鼻咽粘膜上皮非典型增生组织及慢性炎性黏膜组织HTERT的阳性率均为 0 0 % (0 /8及 0 /16) (P <0 0 1) ;⑵鼻咽癌临床TNM分期组间HTERT定性表达率存在显著差异 (P <0 0 5 ) ;有鼻咽癌淋巴结转移的患者 ,其HTERT的阳性表达强度明显增加 (P <0 0 5 ) ;远处转移组间HTERT的阳性表达率及表达强度均未发现显著差异 (P >0 0 5 ) ;⑶HTERT阳性组中位生存期低于阴性组中位生存期 ,两者间存在显著性差异 (P <0 0 5 )。结论 HTERT可作为临床诊断鼻咽癌的一个潜在指标 ,且对预测临床分期、淋巴结转移及预后生存时间有一定的意义
Objective To investigate the expression of human telomerase reverse transcriptase (HTERT) in nasopharyngeal carcinoma and its clinical significance. Methods The expression of HTERT in nasopharyngeal carcinoma, atypical nasopharyngeal mucosa epithelium and nasopharyngeal chronic inflammatory mucosa were detected by immunohistochemistry. The clinical TNM stage, lymph node metastasis, distant metastasis and prognosis were analyzed . Results (1) The positive rate of HTERT in nasopharyngeal carcinoma was 83 4% (70/84). The positive rates of HTERT in atypical hyperplastic nasopharyngeal mucosa and chronic inflammatory mucosa were 0% (0/8 and 0 / 16) (P <0.01). (2) The qualitative expression rate of HTERT in TNM staging patients was significantly different (P <0.05). The positive expression rate of HTERT in patients with lymph node metastasis of nasopharyngeal carcinoma was significantly higher (P <0.05). There was no significant difference in the expression of HTERT between distant metastasis groups (P> 0.05). (3) The median survival time of HTERT positive group was lower than that of negative group , There was a significant difference between the two (P <0 05). Conclusion HTERT can be used as a potential indicator of clinical diagnosis of nasopharyngeal carcinoma, and has certain significance in predicting clinical stage, lymph node metastasis and prognosis