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本文综述近十年来有关恶性骨肿瘤临床治疗方面的进展。着重骨肿瘤的化疗、手术治疗、放疗和免疫治疗等四个方面。化疗是保肢治疗的前提和基础。保肢手术是目前治疗四肢恶性骨肿瘤的主要方法和发展主流。但晚期患者仍以截肢为妥。保留骨骺和骨骺延长的儿童保肢日益受到临床医生的重视。放疗和免疫治疗仅是化疗、手术治疗的辅助手段,但能明显地改善患者的预后。个体化的化疗、保肢方法的改进及功能评价、肿瘤免疫与基因治疗将是今后的研究方向。
This article reviews recent advances in the clinical treatment of malignant bone tumors. Focus on bone tumor chemotherapy, surgical treatment, radiotherapy and immunotherapy in four areas. Chemotherapy is the premise and basis of limb salvage therapy. Limb salvage operation is currently the main method for the treatment of malignant bone tumors of the extremities and the development mainstream. However, patients with advanced stage are still amputated. The limb salvage of children with preserved osteophytes and osteophytes is increasingly valued by clinicians. Radiotherapy and immunotherapy are only supplementary methods for chemotherapy and surgery, but they can significantly improve the prognosis of patients. Individualized chemotherapy, limb salvage method improvement and functional evaluation, tumor immunity and gene therapy will be the future research direction.