采用Ｆｏｇａｒｔｙ导管损伤大鼠胸主动脉段内皮细胞，观察１、５、１５和２０天后胸主动脉组织形态学改变；提取胸主动脉段组织ＲＮＡ采用反转录－多聚酶链反应方法测定原生型一氧化氨合成酶基因和内皮素－１基因ｍＲＮＡ的表达。结果表明，胸主动脉压血管平滑肌细胞在内皮损伤后增殖，内皮素－１基因表达增加，原生型一氧化氮合成酶基因表达减少，提示原生型一氧化氮合成酶基因和内皮素－１基因表达的改变可能在内皮损伤后的平滑肌细胞增殖中起重要作用。 Endothelial cells of thoracic aorta were injured by Fogarty catheter, and the morphology of thoracic aorta was observed after 1, 5, 15 and 20 days. RNA extracted from the thoracic aorta was detected by reverse transcription-polymerase chain reaction Ammonia ammonia synthase gene and endothelin-1 gene mRNA expression. The results showed that thoracic aortic vascular smooth muscle cells proliferated after endothelial injury, the expression of endothelin-1 increased, and the expression of native nitric oxide synthase gene decreased, which suggested that the expression of primary nitric oxide synthase gene and endothelin-1 gene Changes in expression may play an important role in the proliferation of smooth muscle cells after endothelial injury.