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目的评价间歇性雄激素阻断治疗晚期前列腺癌的可行性及优点。方法选取晚期前列腺癌患者59例,随机分为2组。给予间歇性雄激素阻断治疗30例(A组),给予持续雄激素阻断治疗29例(B组),观察两组患者的疾病进展及治疗期间副反应的发生情况,比较两种方法的治疗效果。结果A组患者平均随访26个月,B组患者平均随访27个月,两组患者疾病进展情况未见明显差异。A组患者副反应低于B组患者且能在治疗间歇期得到缓解。结论间歇性雄激素阻断治疗方法可行,能够减少患者治疗的副反应,提高患者生活质量。
Objective To evaluate the feasibility and advantages of intermittent androgen blockade in the treatment of advanced prostate cancer. Methods Fifty-nine patients with advanced prostate cancer were randomly divided into two groups. Given intermittent androgen block treatment in 30 cases (group A), given continuous androgen block treatment in 29 cases (group B), the two groups of patients with disease progression and side effects during treatment compared two methods treatment effect. Results The patients in group A were followed up for an average of 26 months. Patients in group B were followed up for a mean of 27 months. There was no significant difference in disease progression between the two groups. Patients in group A had lower side effects than patients in group B and were relieved during the intermission. Conclusion Intermittent androgen blockade treatment is feasible, which can reduce the side effects of treatment and improve the quality of life of patients.