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目的:评估18F-FDG PET/CT在寻找多发性骨转移瘤原发灶中的临床价值。方法:回顾性分析136例多发性骨转移瘤患者的18F-FDG PET/CT检查资料,并与其病理结果相对照。结果:136例患者中,经18F-FDG PET/CT发现原发灶者共85例,其中79例经手术或活检病理证实为原发灶,另有6例证实为假阳性。51例多发性骨转移瘤未找到原发灶,其中3例在随访中证实为假阴性,其余48例在随后的随访中仍未发现原发灶。利用18F-FDG PET/CT寻找多发性骨转移瘤原发灶的灵敏度为96.3%,特异度为88.9%,符合率为93.4%。有79例患者找到了原发病灶,检出率为58.1%(79/136)。结论:应用18F-FDG PET/CT寻找多发性骨转移瘤的原发灶有一定临床价值,对制定合适的个性化治疗方案有积极作用。
OBJECTIVE: To evaluate the clinical value of 18F-FDG PET / CT in the search for the primary tumor of multiple bone metastases. Methods: The data of 18F-FDG PET / CT in 136 patients with multiple bone metastases were retrospectively analyzed and compared with the pathological results. Results: Of the 136 patients, 85 cases were found by 18F-FDG PET / CT. Among them, 79 cases were proved to be primary tumor by surgery or biopsy, and 6 cases were false positive. 51 cases of multiple bone metastases did not find the primary tumor, of which 3 cases were confirmed at the follow-up of false negative, the remaining 48 cases in the follow-up has not yet found the primary tumor. The 18F-FDG PET / CT was used to find the primary tumor of multiple bone metastases with sensitivity of 96.3%, specificity of 88.9% and coincidence rate of 93.4%. 79 patients found the primary lesion, the detection rate was 58.1% (79/136). CONCLUSION: The use of 18F-FDG PET / CT to find the primary tumor of multiple bone metastases has some clinical value, which has a positive effect on the development of appropriate personalized treatment.