论文部分内容阅读
肝脏是机体具有强大防御功能和再生能力的重要器官之一,相对于细胞增殖来说,成人或动物的肝脏是一个相对静止的器官。在正常肝组织中仅有0.0012%-0.1%的肝细胞进行有丝分裂[1],而大部分肝细胞处于相对静止的G0期。但在肝脏被部分切除、受到药物(如D2氨基半乳糖胺,CCl4)毒害后,残余的或未受到损害的肝细胞可以通过DNA合成和有丝分裂增殖,重建与机体大小相适应的体积。而肝细胞再生停止是由肝脏的重量与个体体重的比例来决定的,当肝脏再生后其重量与整个体重达到一定比例时,肝脏的再生将自动
The liver is one of the most important organs in the body with powerful defense and regeneration capabilities. Compared with cell proliferation, the liver of an adult or animal is a relatively stationary organ. In normal liver tissue only 0.0012% -0.1% of hepatocytes are mitotic [1], whereas most of the hepatocytes are in a relatively stationary G0 phase. However, when the liver is partially excised and after being poisoned by drugs such as D2-galactosamine, CCl4, residual or undamaged hepatocytes can proliferate through DNA synthesis and mitosis to reconstitute the volume that is compatible with the body size. The stop of liver cell regeneration is determined by the ratio of the weight of the liver to the weight of the individual. When the weight of the liver reaches a certain percentage of the total body weight after regeneration, the liver regeneration will be automatic