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糖尿病是一种慢性代谢紊乱疾病,心血管疾病已成为糖尿病患者最严重的并发症和首位死因。可靠的糖尿病动脉粥样硬化动物模型是研究糖尿病动脉粥样硬化机制、探索治疗途径的基础。目前,借助基因手段,通过转基因或基因敲除和/或辅以链脲菌素诱导或饲以高脂饲料,已成功建立了几种糖尿病动脉粥样硬化小鼠模型。
Diabetes is a chronic metabolic disorder that has become the most serious complication and the leading cause of death in people with diabetes. Reliable diabetic atherosclerosis animal model is to study the mechanism of diabetic atherosclerosis, to explore the basis for treatment. At present, several diabetic atherosclerotic mouse models have been successfully established by means of genetic means, transgenic or knockout and / or supplemented with streptozotocin induced or fed with high fat diet.