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目的 了解 2型糖尿病 (T2DM)患者血浆中酰化刺激蛋白 (ASP)及补体C3 与胰岛素抵抗 (IR)及血脂紊乱的相关性 ,探讨ASP与C3 可能参与IR的机制。 方法 根据体质指数 (BMI)将82例T2DM患者分为肥胖组 (BMI≥ 2 5kg/m2 )及非肥胖组 ,同时将 10 5名非糖尿病者分为单纯肥胖(Ob)组 (BMI≥ 2 5kg/m2 )及正常体重对照组。测定ASP、游离脂肪酸 (FFA)、空腹胰岛素 (FIns)、C3 ,空腹血糖 (FPG)、甘油三酯 (TG)、总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)和胰岛素抵抗指数 (HOMA IR)。 结果 非肥胖糖尿病组 [( 6 7± 38)nmol/L]及Ob组患者ASP水平 [( 6 0± 2 9)nmol/L]显著高于对照组 [( 4 5± 2 1)nmol/L],肥胖糖尿病组ASP水平 [( 5 7± 33)nmol/L]也高于对照组 ,但差异无显著意义。肥胖糖尿病组C3 水平 [( 2 8± 1 2 ) g/L]显著高于对照组 [( 1 9± 0 9) g/L]及Ob组 [( 2 1± 0 9) g/L],Ob组ASP/C3 率 ( 0 7± 0 1)显著高于对照组( 0 5± 0 4 )。相关分析结果显示 ,ASP与BMI、TC、FFA及FPG呈正相关 (r =0 191,P =0 0 0 9;r=0 14 6 ,P =0 0 4 9;r =0 132 ,P =0 0 5 ;r =0 14 0 ,P =0 0 5 ) ;C3 与FPG、FIns及HOMA IR呈正相关 (r =0 2 12 ,P =0 0 0 3;r =0 2 6
Objective To investigate the relationship between acylation-stimulating protein (ASP), complement C3, insulin resistance (IR) and dyslipidemia in patients with type 2 diabetes mellitus (T2DM) and to explore the possible mechanism of ASP and C3 involvement in IR. Methods Eighty-two patients with T2DM were divided into obesity group (BMI≥25kg / m2) and non-obese group according to body mass index (BMI). Meanwhile, 105 non-diabetic patients were divided into ob group (BMI≥25kg / m2) and normal weight control group. The levels of ASP, FFA, FIns, C3, FPG, TC, HDL C, Cholesterol (LDL C) and Insulin Resistance Index (HOMA IR). Results Compared with the control group [(45 ± 2 1) nmol / L [(6 7 ± 38) nmol / L] and ASP group ], Obese diabetic ASP group [(57 ± 33) nmol / L] was also higher than the control group, but the difference was not significant. The level of C3 in obese diabetic group was significantly higher than that in control group [(29 ± 0 9) g / L] and Ob group [(2 1 ± 0 9) g / L] Ob group ASP / C3 rate (0 7 ± 0 1) was significantly higher than the control group (0 5 ± 0 4). Correlation analysis showed that there was a positive correlation between ASP and BMI, TC, FFA and FPG (r = 0 191, P = 0 0 9; r = 0 14 6, P = 0 049; r = 0 132, P = 0 0 5; r = 0 14 0, P = 0 05); C3 was positively correlated with FPG, FIns and HOMA IR (r = 0 2 12, P = 0 0 0 3; r = 0 2 6