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目的:探讨容积二氧化碳图(volumetric capnography,VCap)斜率参数对急性发作期支气管哮喘(以下简称哮喘)的诊断价值。方法:对53例急性发作期哮喘患者(哮喘组)及43名健康者(健康组)进行肺通气功能及VCap测定。采用Pearson相关性分析检验肺通气功能与VCap斜率指标间的相关性,采用独立样本t检验比较哮喘组与健康组间的VCap斜率指标差异,并用受试者工作特征曲线(receiver operator characteristic curve,ROC曲线)分析VCap斜率指标对急性发作期哮喘患者与健康人的鉴别效能。结果:Ⅲ相斜率(d C3/DV)、SR23分别与一秒钟用力呼气量(forced expiratory volume in one second,FEV1)占预计值百分比(FEV1/pre)、FEV1/用力肺活量(forced vital capacity,FVC)%呈负相关(P<0.05)。d C2/DV与FEV1/FVC%成正相关(P<0.05)。哮喘组d C3/DV、SR23均较健康组增大,差异有统计学意义(P<0.01)。d C2/DV、d C3/DV和SR23的曲线下面积分别为0.605、0.724、0.757。结论:VCap是一种简便易行的指标,对急性发作期哮喘的诊断具有一定参考价值。
Objective: To investigate the diagnostic value of volumetric capnography (VCap) slope parameters in the diagnosis of bronchial asthma (acute asthma) in acute attack. Methods: Lung function and VCap were measured in 53 patients with asthma (acute asthma) and 43 healthy subjects (healthy group). Pearson correlation analysis was used to test the correlation between pulmonary ventilation function and VCap slope index. The difference of VCap slope between asthma group and healthy group was compared by independent sample t-test. Receiver operator characteristic curve (ROC Curve) analysis of VCap slope indicators of acute attack of asthma patients and healthy people identification efficiency. RESULTS: The FEV1 / pre, FEV1 / forced vital capacity (FEV1 / pre), FEV1 / FEV1 , FVC)% was negatively correlated (P <0.05). d C2 / DV was positively correlated with FEV1 / FVC% (P <0.05). The d C3 / DV and SR23 in the asthma group were significantly higher than those in the healthy group (P <0.01). The area under the curve of d C2 / DV, d C3 / DV and SR23 were 0.605, 0.724 and 0.757, respectively. Conclusion: VCap is a simple and easy-to-use indicator that has certain reference value for the diagnosis of acute asthma.