太赫兹光谱技术在药物定性定量检测上的应用

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为判断药物的真伪,检查药物的纯度,以及克服目前化学药物定性定量检测中耗时长、损耗样本、操作繁琐等缺陷,提出了一种基于太赫兹光谱技术的快速且能准确定性和定量药物的检测方法。基于太赫兹吸收光谱,提取了氯雷他定、消旋卡多曲的特征峰频点以及峰下面积差特征,并通过这些信息来对药物进行定性与定量检测。实验结果表明:在定量检测中,太赫兹光谱技术具有高的稳定性及检测精度;质量分数梯度变化的线性拟合相关系数达到99.8%;在结合主成分分析法(principal component analysis,PCA)对其他药物的检测中,太赫兹光谱技术定性检测准确率可达100%,定量检测误差小于0.01。这些结果可为后续药物的快速、准确和无损检测提供参考。“,”In order to judge the authenticity of the drug and to check the purity of the drug, and to overcome the shortcomings of the long time consuming, sample loss and complicated operation in the current qualitative and quantitative detection of chemical drugs, a fast, quasi determinacy and quantitative method for drug detection based on terahertz spectroscopy is proposed. Based on the terahertz absorption spectrum, the characteristic peak frequency points and the area difference of loratadine and racecadotril were extracted. The qualitative and quantitative detection of the drugs was carried out by using these information. In quantitative detection, stability and accuracy of terahertz spectrum are high. In the establishment of concentration gradient, the linear fitting correlation coefficient reaches 99.8%. Meanwhile, principal component analysis (PCA) was used to detect other drugs. The results showed that the accuracy of qualitative detection was 100%, and the error of quantitative detection was less than 0.01. These results can provide reference for the rapid, accurate and nondestructive testing of the following drugs.
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