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HBV X蛋白(HBx)是多功能蛋白,能转录激活多种病毒及细胞基因,从而参与病毒复制以及宿主细胞的基因调控、蛋白降解和细胞信号转导等过程。近期研究发现HBx可以定位在线粒体上,干扰线粒体氧化磷酸化等能量代谢过程,促进细胞凋亡。氧化应激是指人体的组织细胞中自由基产生增多,并且由于自由基清除酶的活性下降、数量减少等原因,使得机体的抗氧化能力下降的现象,反映了体内氧化和抗氧化系统间的失衡。本文从HBx在线粒体的定位以及与HBx结合的蛋白,从相关的分子机制阐明HBx与氧化应激的相关作用。
HBV X protein (HBx) is a multi-functional protein that transcribes and activates a variety of viruses and cellular genes, thereby participating in viral replication and gene regulation of host cells, protein degradation and cell signal transduction. Recent studies have found that HBx can locate on the mitochondria, interfere with mitochondrial oxidative phosphorylation and other energy metabolism processes, and promote apoptosis. Oxidative stress refers to the increase of free radicals in the tissue cells of the human body, and the decrease of the antioxidant capacity of the body due to the decrease of the activity of the free radical scavenger and the decrease of the quantity reflects the relationship between the oxidation and antioxidant systems in vivo Imbalance In this paper, the correlation between HBx and oxidative stress was elucidated from the molecular mechanism of the localization of HBx in mitochondria and the protein binding to HBx.