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微纳传感技术在研究组织和细胞的电生理活动、揭示细胞网络属性、研究神经传导及药物安全性测试等方面展现了它独特优势。针对组织电生理检测的多种微纳传感技术及其特点进行了描述与评价,着重对多点实时监测的微阵列传感技术的研究和应用进展进行了详细介绍和讨论。最后结合本实验室的研究工作,介绍了微电极阵列技术在嗅觉组织研究中的进展。在探索细胞的离子通道、突触特性及细胞内信号转导时,玻璃微电极记录特别是膜片钳技术是目前比较理想的手段;在研究信号传导、突触传递时,多电极阵列具有明显的优势。微电极传感阵列技术是未来神经科学研究的主要方法之一,它将在提高信噪比及生物相容性、减少对组织的损伤、扩大应用等方面有新的发展。
Micro-nano-sensing technology has demonstrated its unique advantages in studying the electrophysiological activities of tissues and cells, revealing the properties of cellular networks, studying nerve conduction and drug safety testing. A variety of micro-nano sensing techniques for tissue electrophysiological detection and their characteristics are described and evaluated, and the research and application progress of multi-point real-time monitoring microarray sensing technology are introduced and discussed in detail. Finally, combined with the research work of our laboratory, the progress of the research on olfactory tissue with microelectrode array technology is introduced. In exploring cell ion channels, synaptic properties and intracellular signal transduction, glass microelectrode recording, especially patch clamp technique, is an ideal method at present; when studying signal transduction and synaptic transmission, the multi-electrode array has obvious The advantages. Microelectrode sensing array technology is one of the main methods of neuroscience research in the future. It will have new development in improving signal-to-noise ratio and biocompatibility, reducing damage to the tissue and expanding application.