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目的:了解某医院儿童药品不良反应(ADR)的发生和分布情况,为临床合理用药提供参考。方法:对某院2010年1～6月收集到的小儿ADR 130例,从性别、年龄、引发ADR的药品种类、给药途径、ADR累及器官或系统及临床表现等方面进行统计分析。结果:年龄<3岁患儿发生ADR的比例最高(82例,63.08%);静脉滴注给药引发ADR的比例最高(97例,74.62%);引起ADR的药品有5类31种,其中抗肿瘤药引起的ADR最多(66例,46.81%)。结论:必须重视小儿ADR的监测和报告,尽量减少或避免ADR发生。
Objective: To understand the occurrence and distribution of children’s adverse drug reaction (ADR) in a hospital so as to provide reference for clinical rational drug use. Methods: 130 cases of pediatric ADR collected in a hospital from January to June in 2010 were analyzed statistically according to gender, age, drug type, route of administration, organs or systemic and clinical manifestations of ADR. Results: The highest ADR occurred in children <3 years of age (82 cases, 63.08%). The highest proportion of ADR was induced by intravenous drip infusion (97 cases, 74.62%). There were 5 types of 31 ADR drugs Antitumor drugs caused the most ADRs (66 cases, 46.81%). Conclusion: We must pay attention to the monitoring and reporting of ADR in children to minimize or avoid the occurrence of ADR.