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探讨P-糖蛋白与中药药性理论的相关性与研究现状,更好开展和利用P-糖蛋白方法用于中药药性理论的研究。介绍了中药药性理论的引经药、配伍关系、配伍解毒等与P-糖蛋白关系的最新进展,提出P-糖蛋白方法用于中药药性理论研究的思考。同时,综合分析了用于研究中药药性理论与P-糖蛋白关系的相关研究方法,包括细胞模型法、基因敲除动物模型法、在体肠灌流法、计算机模拟等的技术特点。一些中药成分能影响P-糖蛋白的活性,可从跨膜蛋白的角度研究中药成分在体内过程的相互作用。通过P-糖蛋白理论与方法的应用,可为中药药性理论的研究提供崭新的思路,有利于促进学科交叉渗透,提高中医药传统理论的现代研究与应用水平。
To explore the relevance and research status of P-glycoprotein with the theory of Chinese medicinal properties and to better develop and utilize the P-glycoprotein method in the study of the theory of Chinese medicinal properties. This paper introduces the newest progress on the relationship between lead drugs, compatibility, detoxification and other P - glycoproteins of traditional Chinese medicine theory of pharmacology, and puts forward the thinking of applying P - glycoprotein method to theoretical research of Chinese medicine pharmacodynamics. At the same time, the related research methods used to study the relationship between TCM theory and P-glycoprotein were comprehensively analyzed, including cell model method, animal model of knockout, in vivo intestinal perfusion method, computer simulation and so on. Some traditional Chinese medicine can affect the activity of P-glycoprotein, the interaction of traditional Chinese medicine components in vivo process from the perspective of transmembrane protein. Through the application of the theory and method of P-glycoprotein, it can provide a new idea for the study of the theory of Chinese medicinal properties, promote cross-disciplinary penetration and improve the modern research and application level of traditional Chinese medicine theory.