Objective:This study investigated the ameliorative potential of Zingiber officinale Roscoe extract against lead-induced brain damage in rats.Methods:Thirty male rats were divided into 5 groups of 6 rats each.Lead-acetate toxicity was induced by intraperitoneal injection (10 mg/kg body weight (b.w.)) in Groups B-E.Group A (control) and Group B (lead-acetate) were left untreated;vitamin C (200 mg/kg b.w.) was administered to Group C;ethyl acetate fraction from Z.officinale extract (200 and 100 mg/kg b.w.) was administered to Group D and E by oral gavage once daily for 7 days.Changes in the content of some key marker enzymes such as acetylcholinesterase (ACHE),butyrylcholinesterase (BChE),monoamine oxidase (MAO),epinephrine,dopamine,Na+/K+-ATPase,catalase (CAT),superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as malonaldehyde (MDA) levels were determined in serum.Results:Exposure to lead acetate resulted in a significant decrease (P ＜ 0.05) in the activities of BChE,ACHE,Na+/K+-ATPase,SOD,CAT and GPx with a corresponding increase in the levels of MDA,xanthine oxidase,epinephrine,dopamine and MAO relative to the control group.Levels of all disrupted parameters were alleviated by co-administration ofZ.officinale fraction and by the standard drug,vitamin C.Conclusion:These results suggest that ethyl acetate fraction of Z.officinale extract attenuates leadinduced brain damage and might have therapeutic potential as a supplement that can be applied in lead poisoning.