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目的探讨CA125、CA199、CEA和AFP四种肿瘤标志物在肿瘤性疾病诊断中的临床意义和应用价值。方法采用放射免疫分析方法(RIA)检测。结果①在肝脏良、恶性两组疾病中,血清CA125、CA199和AFP水平均高于正常对照组,其中肝癌组AFP又明显高于良性病变组(P<0.01);对于单检的诊断效率,AFP高于其他指标;另外,CA199、CEA和AFP联检在敏感性、特异性及准确性上均显著高于单检组;②在卵巢癌和良性病变组,血清CA125和CA199水平均高于正常对照组,其中卵巢癌组CA125又明显高于良性病变组(P<0.01);对于单检的诊断效率,CA125高于其他指标;另外,CA199、CEA和CA125联检在敏感性、特异性及准确性上均显著高于单检组。结论应用多项指标联检可以提高肝癌和卵巢癌的诊断效率。
Objective To investigate the clinical significance and clinical value of four tumor markers CA125, CA199, CEA and AFP in the diagnosis of neoplastic diseases. Methods The radioimmunoassay (RIA) method was used to detect. Results ① The levels of serum CA125, CA199 and AFP were higher in benign and malignant liver disease than in normal control group, and the AFP in hepatocellular carcinoma was significantly higher than that in benign lesions (P <0.01). For the diagnostic efficiency, AFP higher than other indicators; In addition, CA199, CEA and AFP joint examination in the sensitivity, specificity and accuracy were significantly higher than the single test group; ② in ovarian cancer and benign lesions, serum CA125 and CA199 levels were higher than normal In the control group, CA125 in ovarian cancer group was significantly higher than that in benign lesion group (P <0.01). For the diagnostic efficiency of single examination, CA125 was higher than other indicators. In addition, the combination of CA199, CEA and CA125 was sensitive, specific and accurate Sex were significantly higher than the single test group. Conclusion The combination of multiple indicators can improve the diagnostic efficiency of liver cancer and ovarian cancer.