目的:比较4种常用抗生素对胸外科患者术后预防感染的效果-成本。方法:选取2014年10月-2016年11月间收治的行胸外科手术治疗的肺癌患者120例作为本次研究资料,按照双盲法将其分为头孢呋辛组、哌拉西林他唑巴坦钠组、头孢西丁组和头孢唑肟组,每组30例;比较每组患者用药后的疗效和最小成本。结果:头孢呋辛组为(1 021.3±294.5)元、哌拉西林-他唑巴坦钠组患者成本费用为(1 895.60±612.50)元、头孢唑肟组为(2 572.0±867.7)元和头孢西丁组为(1 562.7±488.7)元,头孢呋辛组的治疗方案均优于其他3组,其总有效率每1个百分点仅花费11.78元,经组间数据比较其差异有统计学意义(P<0.05)。结论:对术后感染患者采用头孢呋辛治疗的方案为最好佳,其药物经济学优势更为显著。 OBJECTIVE: To compare the effect of four commonly used antibiotics on postoperative infection prevention in thoracic surgery patients - cost. Methods: A total of 120 patients with lung cancer underwent thoracic surgery from October 2014 to November 2016 were selected as the data of this study. They were divided into cefuroxime group, piperacillin and tazobactam Sodium group, cefotaxime group and ceftizoxime group, with 30 cases in each group. The curative effect and minimum cost of each group were compared. Results: The cost of ceftiofurin group was (1 021.3 ± 294.5) yuan, the cost of piperacillin-tazobactam sodium group was (1 895.60 ± 612.50) yuan and that of ceftizoxime group was (2 572.0 ± 867.7) yuan Cefoxitin group was (1,562.7 ± 488.7) yuan, the treatment of cefuroxime group were better than the other three groups, the total effective rate of 1 percentage point for only 11.78 yuan, the data between groups were statistically significant differences Significance (P <0.05). Conclusion: Cefuroxime has the best regimen for patients with postoperative infection, and its drug economics advantage is more obvious.