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目的分析辽宁省1999-2005年度流感的病原学及流行特征。方法在流行季节采集咽拭子用鸡胚和细胞分离方法,进行间接血凝抑制试验。结果1999年11月至2005年3月末,辽宁省及省内其他6市疾病预防控制中心(CDC)共采集咽拭子标本2713份,分离流感病毒188株,平均分离率为7.0%;其中辽宁省CDC和大连市CDC共采集标本1466份,分离病毒167份,平均分离率为11.4%;在2002年以前均分离到A3、A1和B型,且B型为Yamagata谱系;2002年后再未见A1型出现,A3与B型优势并重,且抗原分析显示B型已与Victoria谱系更类似。辽宁省作为北方省在中国-WHO第一个五年流感监测项目中只进行秋冬季监测,发现流行期出现在当年11月份至次年2月份。结论辽宁省不同年份流感病原学监测结果的分析对于了解辽宁省流感流行特点、亚型漂移、对流感乃至禽流感的监测与预防控制具有重要意义。
Objective To analyze the etiology and epidemiology of influenza in Liaoning Province from 1999 to 2005. Methods Throat swabs were collected during the epidemic season using chicken embryos and cell isolation methods for indirect hemagglutination inhibition tests. Results From November 1999 to the end of March 2005, 2713 samples of throat swabs and 188 isolates of influenza virus were collected from Liaoning Province and other six CDC centers in the province, with an average isolation rate of 7.0%. Among them, Liaoning A total of 1466 specimens were collected from CDC and CDC in Dalian, 167 were isolated from the virus and the average isolation rate was 11.4%. A3, A1 and B were isolated before 2002, and type B was Yamagata lineage. See Type A1, both A3 and B together, and antigen analysis shows that type B is more similar to the Victoria pedigree. Liaoning Province as the northern province in China - the first five-year influenza surveillance project in the WHO only autumn and winter monitoring, found that the epidemic occurred in November of the year to February of the following year. Conclusion The analysis of influenza etiology monitoring results in different years in Liaoning Province is of great significance for understanding the epidemic characteristics of influenza, sub-type drift, monitoring of influenza and even bird flu in Liaoning Province.