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目的:探讨依那西普不同给药方式对强直性脊柱炎(AS)的疗效影响。方法:64例AS随机分成甲、乙2组,2组均给予依那西普皮下注射。甲组每周2次,25 mg/次;乙组每周1次,50 mg/次。连续注射12周。在治疗前、治疗1、6、12次和治疗后20天分别进行疗效评估。结果:2组ASAS20和ASAS50改善情况有一定差异,但差异均无统计学意义(P>0.05)。结论:依那西普每周1次,50 mg/次的方案经济、方便。
Objective: To investigate the effect of etanercept on the curative effect of ankylosing spondylitis (AS). Methods: 64 cases of AS were randomly divided into A, B group 2, two groups were given etanercept subcutaneous injection. Group A twice a week, 25 mg / time; Group B once a week, 50 mg / time. Continuous injection of 12 weeks. Before treatment, the treatment of 1, 6, 12 and 20 days after treatment were evaluated. Results: The improvement of ASAS20 and ASAS50 in two groups were different, but the differences were not statistically significant (P> 0.05). Conclusion: Etanercept once a week, 50 mg / time program economy and convenience.