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This study investigated the relationship betweenhuman papillomavirus (HPV) genotype and expression of p53and p21WAF1. Expression of p53 and p21WAF1 in 35 cases ofcondyloma acuminatum specimens infected by HPV6/11andHPV16/18 were studied using immunohistochemical staining.All specimens of the condyloma acuminatum case were positivefor expression of p53 and p21 WAFt. The expression of p53 incondyloma acuminatum infected by HPV16/18 wassignificantly lower than that in specimens infected byHPV6/11.However, expression of p21WAF1 between the twogroups was not significantly different. Expression of p53 incondyloma acuminatum is likely related to HPV genotype,expression of p21WAF1 was not related to HPV genotype.