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中药有效成分煎煮时的溶出率直接影响疗效,加工、煎煮条件、配伍等对有效成分溶出率都有一定影响,提高有效成分的溶出率,对增强疗效很有意义。我们以黄连小檗碱为其有效成分作指标,探讨调剂,配伍对黄连中小檗碱溶出率的影响,为控制中药制剂质量提供参考。实验材料1.黄连及各种药材:购自郑州医药公司。2.盐酸小檗碱标准品:上海第二军医
The dissolution rate of the active ingredients of traditional Chinese medicine directly affects the curative effect. The processing, decoction conditions, and compatibility all have a certain influence on the dissolution rate of the active ingredient. Increasing the dissolution rate of the active ingredient is of great significance for enhancing the curative effect. We used Coptis berberine as an effective ingredient as an index to investigate the effects of preparations and compatibility on the dissolution rate of berberine in Coptis chinensis, in order to provide reference for the quality control of traditional Chinese medicine preparations. Experimental Materials 1. Rhizoma Coptidis and various medicinal materials: Purchased from Zhengzhou Pharmaceutical Company. 2. Berberine hydrochloride standard: Shanghai Second Military Medical Officer