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目的探讨大剂量免疫球蛋白联合依达拉奉对病毒性脑炎的辅助治疗作用。方法将60例病毒性脑炎患者随机分为研究组(30例)和对照组(30例),对照组采用常规治疗方法(阿昔洛韦抗病毒、脱水降颅压、激素、退热以及镇静、止痫等对症治疗);研究组在对照组治疗方法的基础上同时给予免疫球蛋白、依达拉奉治疗。观察两组病人临床疗效、脑电图、脑脊液改变情况。结果两组病人总有效率分别为90.00%和60.00%(P<0.05),中度及重度异常脑电图比率分别为10.00%和33.33%(P<0.05),脑脊液常规生化指标有效率比较分别为80.00%和53.33%(P<0.05)。结论大剂量免疫球蛋白联合依达拉奉辅助治疗病毒性脑炎能提高疗效,值得临床推广。
Objective To investigate the adjuvant therapeutic effect of high-dose immunoglobulin combined with edaravone on viral encephalitis. Methods Sixty patients with viral encephalitis were randomly divided into the study group (30 cases) and the control group (30 cases). The control group was treated with routine therapy (acyclovir antivirus, dehydration intracranial pressure, hormone, fever and Sedation, seizures and other symptomatic treatment); study group in the control group based on the treatment of both immunoglobulin, edaravone treatment. Clinical efficacy, EEG and cerebrospinal fluid changes were observed in two groups of patients. Results The total effective rates of the two groups were 90.00% and 60.00%, respectively (P <0.05). The rates of moderate and severe abnormal EEG were 10.00% and 33.33% (P <0.05) respectively. The routine biochemical indexes of cerebrospinal fluid 80.00% and 53.33% (P <0.05). Conclusion The combination of high-dose immunoglobulin and edaravone in the treatment of viral encephalitis can improve the curative effect and is worthy of clinical promotion.