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目的:制备丹皮酚微囊,研究其释药机制。方法:以不同浓度海藻酸钠制备微囊,在不同释放介质中测定考察药物释放度,并采用释药动力学模型拟合探讨其释药机制。结果:海藻酸钠浓度增加,微囊载药量及释放度降低,酸性介质有利于药物初期释放,碱性介质有利于药物后期释放,体外释放符合一级动力学方程。结论:该微囊制备工艺简单,释药机制是以骨架溶蚀为主兼有药物扩散的非Fickian过程。
Objective: To prepare paeonol microcapsules and investigate the mechanism of drug release. Methods: The microcapsules were prepared with different concentrations of sodium alginate. The drug release was measured in different release media. The drug release mechanism was studied by using the release kinetic model. Results: The concentration of sodium alginate increased, the microcapsule drug loading and release decreased. The acidic medium was favorable for the initial drug release. The alkaline medium was good for the late drug release. The in vitro release was in accordance with the first order kinetic equation. Conclusion: The microcapsule preparation process is simple, drug release mechanism is a non-Fickian process based on skeleton dissolution with drug diffusion.