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肝纤维化是机体对各种慢性肝损伤的自我修复反应,肝组织内细胞外基质(ECM)成分过度增生与异常沉积,导致肝脏结构及功能异常,也是各种慢性肝病的病理学基础。成功复制与各种原因引起的人类肝纤维化相似的动物模型是研究肝纤维化发病机制及防治肝纤维化实验研究的前提。文章就目前常用的几种肝纤维化动物模型的建立方法、用途及每种模型的优缺点进行综述。
Liver fibrosis is a self-repairing reaction of various chronic liver injuries. Liver tissue is over-proliferated and abnormally deposited with extracellular matrix (ECM) components, resulting in abnormal liver structure and function. It is also the pathological basis of various chronic liver diseases. Successful replication of animal models of human liver fibrosis caused by various causes is a prerequisite for the study of the pathogenesis of liver fibrosis and prevention and treatment of hepatic fibrosis. This article reviews several commonly used methods, applications and advantages and disadvantages of each animal model of hepatic fibrosis.