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目的 :检测正常人及再生障碍性贫血 (AA) ,骨髓增生异常综合征 (MDS) ,急性白血病 (AL) ,缺铁性贫血 (IDA)患者血清EPO浓度 ,探讨该类贫血发生的机制。方法 :ELISA法测定正常人及AA、MDS、AL、IDA患者血清EPO浓度。结果 :AA、MDS患者血EPO浓度较正常明显增高 ,P <0 .0 1,AL患者血EPO浓度较正常增高 ,统计学有显著性差异 ,P <0 .0 5 ,DIA患者血EPO浓度较正常高 ,但无统计学意义。结论 :EPO浓度除与缺氧及Hb水平有关外 ,可能还与骨髓功能有关
Objective: To detect the concentration of serum EPO in normal subjects and patients with aplastic anemia (AA), myelodysplastic syndrome (MDS), acute leukemia (AL) and iron deficiency anemia (IDA) and to explore the mechanism of such anemia. Methods: Serum levels of EPO in normal subjects, AA, MDS, AL and IDA were measured by ELISA. Results: The levels of EPO in AA and MDS patients were significantly higher than those in normal controls (P <0.01). The blood levels of EPO in AL patients were significantly higher than those in normal controls (P <0.05) Normal high, but not statistically significant. Conclusion: EPO concentration in addition to hypoxia and Hb levels may be related to bone marrow function