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目的:研究细辛的主治病证、配伍特点和常用剂量,为临床合理使用细辛提供参考。方法:收集历代中医方剂文献中含细辛的方剂,采用SQL Server 2008构建细辛方数据库,釆用SPSS 19统计频数、均值等参数、运用SQL Server 2008开展数据的关联分析。从内服和外用2个方面分析细辛方的主治病证范围、配伍特点及常用剂量。结果:共釆集到4 489首含细辛的方剂;从内服和外用2个方面分别挖掘出了细辛方主治频数最高的前15个病证、配伍频数最高的前10味中药;确定细辛内服汤剂的常用剂量范围为1.85~13.75 g。结论:细辛的主治病证与药物配伍存在着明显的关联性;从汉朝至南北朝到清代呈现出依次递减的规律;细辛临床常用剂量以1.85~13.75 g为宜,针对不同的病证,可以配伍不同的方药、使用不同的剂量,不应受“细辛不过钱”的观点所束缚。
Objective: To study the main Syndromes of Asarum Syndromes, compatibility characteristics and commonly used doses for the clinical use of Asarum provide a reference. Methods: The traditional Chinese medicine prescriptions containing Asarum prescriptions were collected. SQL Server 2008 was used to construct Asarum database. SPSS 19 was used to calculate the frequency and mean of the data and SQL Server 2008 was used to analyze the data. From the two aspects of oral administration and topical analysis of Asarum side attending the scope of the disease, compatibility characteristics and commonly used doses. Results: A total of 4 489 prescriptions containing Asarum were collected. The top 15 TCM syndromes with the highest frequency of Asarum prescription and the top 10 traditional Chinese herbs with the highest frequency of association were excavated from two aspects of oral administration and external application. Commonly used dose of the capsaicin decoction is 1.85 ~ 13.75 g. Conclusion: Asarum indica syndrome has obvious association with drug compatibility. From Han dynasty to Southern and Northern Dynasties and Qing dynasty, the order of diminishing is presented. The common clinical dose of Asarum is 1.85 ~ 13.75 g, Syndromes can be compatible with different prescriptions, use different doses, should not be “Asarum but money” point of view.