目的了解大面积烧伤并发肺部感染的常见致病菌、传播途径及部分抗生素耐药率。方法从1988年1月￣2002年12月收治的大面积烧伤并发肺部感染的患者中,选择痰、血和创面分泌物培养均齐全的41例,对其细菌学特点、药物耐药性及肺部感染的传播途径进行总结分析。结果大面积烧伤并发肺部感染的致病菌G(r-)杆菌明显高于G(r+)球菌。部分肺炎可能源于血行传播。革兰氏阳性球菌对万古霉素、头孢霉素类等抗生素的耐药率较低。革兰氏阴性杆菌的耐药率较高。结论大面积烧伤并发肺部感染的患者致病菌与一般肺炎不同,其细菌学特点和对抗生素的耐药率对临床选用抗生素有参考价值。 Objective To understand the common pathogens, routes of transmission and some antibiotic resistance rates in large area burn patients with pulmonary infection. Methods From January 1988 to December 2002 admitted to the large area of ​​patients with lung infection complicated with burn, choose the sputum, blood and wound secretions were 41 cases of complete culture, its bacteriological characteristics, drug resistance and Pulmonary infection transmission ways to summarize the analysis. Results The pathogen G (r-) bacilli in large-area burn patients with pulmonary infection was significantly higher than that of G (r +). Some pneumonia may be due to blood transmission. Gram-positive cocci vancomycin, cephalosporins and other antibiotics resistance rate is low. Gram-negative bacilli higher resistance rate. Conclusions The pathogenic bacteria in patients with large area burn complicated with pulmonary infection are different from those in common pneumonia. The bacteriological characteristics and resistance rate to antibiotics have reference value for clinical use of antibiotics.