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目的探讨星形细胞瘤瘤周水肿与肿瘤血管生成及病理分级的相关性。方法分析了60例经病理证实及免疫组化染色的星形细胞瘤的瘤周水肿与微血管密度(MVD)、肿瘤恶性程度、部位和大小的关系。结果瘤周水肿与MVD、肿瘤的良恶性、部位及大小呈正相关,Ⅰ级星形细胞瘤的瘤周水肿轻,Ⅱ~Ⅳ级瘤周水肿明显;位于皮髓交界区的肿瘤,瘤周水肿最明显;肿瘤越大,水肿越明显。结论星形细胞瘤瘤周水肿与MVD、病理分级、部位及大小关系密切,Ⅱ度以上的瘤周水肿,97·4%为Ⅱ~Ⅳ级星形细胞瘤;肿瘤直径大于5·8cm,多为Ⅱ~Ⅳ级星形细胞瘤。
Objective To investigate the correlation between astrocytoma peritumoral edema and tumor angiogenesis and pathological grade. Methods The relationship between peritumoral edema and microvessel density (MVD), malignancy degree, location and size of astrocytoma in 60 cases of pathologically confirmed and immunohistochemically stained astrocytomas was analyzed. Results Perivascular edema was positively correlated with MVD, benign and malignant tumor location and size. Grade Ⅰ astrocytoma was mild in peritumoral edema and obvious in peritumoral edema in grade Ⅱ ~ Ⅳ. Tumor located in the junction of the spinal cord and peritumoral edema The most obvious; the larger the tumor, the more obvious edema. Conclusion Astrocytoma with edema and MVD, pathological grade, location and size are closely related to the second degree of peritumoral edema, 97.4% grade Ⅱ ~ Ⅳ astrocytoma; tumor diameter greater than 5.8cm, and more Ⅱ ~ Ⅳ grade astrocytoma.