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类风湿性关节炎(RA)是一种常见的慢性自身免疫性疾病,发病机制不明。目前诊断RA的检验指标为抗瓜氨酸化蛋白抗体(ACPA)及类风湿因子(RF)。尽管ACPA及RF有较高的诊断价值,但仍需要探寻新的检验指标提高疾病的诊断率。氨基甲酰化是一种造成蛋白质结构及功能改变的非酶介导的翻译后修饰,与RA的发病有关。近年来研究发现,氨基甲酰化蛋白刺激机体产生的抗氨基甲酰化蛋白抗体作为新的指标,对RA有预测、诊断及判断预后的价值。本综述主要对氨基甲酰化、抗氨基甲酰化蛋白抗体以及它们在RA中的作用进行分析。
Rheumatoid arthritis (RA) is a common chronic autoimmune disease, the pathogenesis is unknown. The current diagnostic criteria for RA are anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF). Although ACPA and RF have higher diagnostic value, but still need to explore new test indicators to improve the diagnosis rate of the disease. Carbamylation is a non-enzymatic, post-translational modification of the structure and function of proteins that contributes to the pathogenesis of RA. In recent years, the study found that carbamylated protein to stimulate the body to produce anti-carbamylated antibody as a new indicator of RA have prognosis, diagnosis and prognosis of the value. This review focuses on the analysis of carbamylated, anti-carbamylated antibodies and their role in RA.