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β阻滞剂通常用于治疗没有特殊禁忌症的心绞痛,但往往因只获部分缓解而需加用第2种药物。异搏定(verapamil)是强有力的冠脉扩张药,本研究评价在口服心得安的患者中加用异搏定的抗心绞痛疗效及本药的安全性。研究对象为稳定型心绞痛患者10例,给予心得安每日剂量平均为218(范围60～360)mg,心绞痛未能完全缓解。本试验为双盲研究,于隔日早晨给予口服单剂异搏定120mg 或安慰剂。患者先经踏车运动试验的训练,其工作负荷每3min 增加20W(瓦特),以使心绞痛于第3～6 min
Beta blockers are commonly used to treat angina without specific contraindications, but second drugs are often added for partial relief. Verapamil is a potent coronary dilator and this study evaluated the efficacy and safety of verapamil in the treatment of oral propranolol. The subjects were 10 patients with stable angina pectoris, the average daily dose of propranolol given 218 (range 60 ~ 360) mg, angina pectoris failed to complete remission. This is a double-blind study. Oral single-dose verapamil 120 mg or placebo was given the next morning. Patients treadmill exercise test training, the workload increase every 20 minutes 20W (watts), so angina at 3 ~ 6 min