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适时适度促进PMN凋亡继之被吞噬细胞吞噬是安全、快速、非炎性清除PMN的有效途径。信号转导通路在PMN凋亡的调控中起重要作用 ,深入研究这些信号转导通路及其相互关系 ,对适当控制炎症反应 ,避免炎症的加重和迁延具有重要意义。
Proper and timely promotion of apoptosis of PMN followed by phagocytosis of phagocytes is an effective, safe and rapid non-inflammatory PMN clearance. Signal transduction pathway play an important role in the regulation of PMN apoptosis. To study these signal transduction pathways and their interrelationship is of great significance for proper control of inflammatory response and avoidance of aggravation and prolongation of inflammation.