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目的观察硫辛酸联合丹红注射液治疗2型糖尿病周围神经病变(DPN)的临床疗效。方法 294例2型糖尿病合并周围神经病变患者随机分为治疗组和对照组,各147例。对照组给予糖尿病饮食,并进行常规糖尿病治疗控制血糖水平基础上加α-硫辛酸。治疗组在对照组的基础上加用丹红注射液;比较两组治疗前后症状、体征变化以及双侧腓神经运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)。结果两组治疗后症状、体征明显改善。治疗组总有效率91.2%大于对照组53.1%,两组治疗后总有效率比较差异有统计学意义(P<0.05);治疗前后MNCV与SNCV改善明显。结论硫辛酸联合丹红治疗2型糖尿病周围神经病变疗效显著。
Objective To observe the clinical efficacy of lipoic acid combined with Danhong injection in the treatment of type 2 diabetic peripheral neuropathy (DPN). Methods A total of 294 patients with type 2 diabetes mellitus and peripheral neuropathy were randomly divided into treatment group and control group, with 147 cases each. The control group was given diabetic diet, and the treatment of conventional diabetes on the basis of blood glucose control plus alpha lipoic acid. The treatment group was given Danhong injection on the basis of the control group. The changes of symptoms and signs and the bilateral peroneal nerve motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) were compared between the two groups before and after treatment. Results After treatment, the symptoms and signs of the two groups were significantly improved. The total effective rate of the treatment group was 91.2%, which was significantly higher than that of the control group (53.1%). The total effective rate of the two groups after treatment was statistically significant difference (P <0.05). MNCV and SNCV improved significantly before and after treatment. Conclusion Lipoic acid combined with Danhong treatment of type 2 diabetic peripheral neuropathy significant effect.